As Roger Federer and Novak Djokovic sailed into the second round James Blake's miserable Wimbledon record continued as he crashed out.
The 17th seed, who has failed to make it past the third round in six previous appearances at the All England Club, was beaten 7-5 6-4 7-6 (7/5) by Italy's Andreas Seppi on Court Three.
Blake would have expected better having reached the recent final at Queen's Club and he was at a loss to explain his poor showings at Wimbledon.
"I was playing pretty well at Queen's, I thought I had a good chance to do well here," he said.
"This has probably been my worst slam and I don't understand why. I just didn't feel like myself out there today. Andreas played well when he had to and I didn't."
Following top seed Rafael Nadal's withdrawal on Friday because of tendinitis in his knees, Blake also took the opportunity to hit out at the packed nature of the international tennis schedule.
"When we're playing slams, it's three out of five (sets) but we get a day off in between. You're able to rest," he continued.
"(In) Masters Series you're playing two of three (sets) but you're playing six matches in seven days. That's pretty rough, especially for someone like him that's generally in the semis or finals of those tournaments.
"I know I'm probably not supposed to say anything about the schedule or about the ATP in that way, but it's just tough for guys."
Spaniard Feliciano Lopez was another casualty in the first round, the 21st seed losing 1-6 7-5 6-3 4-6 10-8 to Slovakia's Karol Beck in a marathon match on Court 18.
Federer, the highest seed following Nadal's withdrawal, got off to a relatively slow start in his first match on grass this year but upped his game to see off Yen-Hsun Lu 7-5 6-2 6-3.
The Swiss star, who will play Guillermo Garcia-Lopez in round two, said: "That was a tough first set. He's beaten some good players and I knew the danger."
Serbian Djokovic was given a much sterner test by Julien Benneteau, losing the first set before eventually coming through 6-7 (8/10) 7-6 (7/1) 6-2 6-4, with the Frenchman needing treatment at match point after slipping at the back of the court.
Thirteenth seed Robin Soderling, beaten by Federer in the final of the French Open two weeks ago, lost his first set to Luxembourg's Gilles Muller before triumphing 6-7 (4/7) 7-5 6-1 6-2.
Another seed taken to four sets was France's Jo-Wilfried Tsonga, the ninth seed, who eventually battled past Kazakhstan's Andrey Golubev 6-3 5-7 7-6 (7/4) 7-6 (7/5) in a match lasting more than three hours.
Seventh seed Fernando Verdasco had an easier time of it against British wild-card entry James Ward, winning 6-1 6-3 6-4, while 15th seed Tommy Robredo beat Luka Gregorc 7-6 (7/4) 6-4 5-7 7-6 (7/3) and big-serving Ivo Karlovic, seeded 22nd, defeated Lukas Lacko 6-3 7-6 (7/4) 6-3.
Karlovic, the 6ft 10in Croatian who served a record 55 aces in his first-round defeat by Lleyton Hewitt at the French Open, smashed down another 32 today.
Karlovic's compatriot Marin Cilic, seeded 11th, eased past Alberto Martin 6-3 6-4 6-4.
Of the other seeds in action, German Philipp Kohlschreiber, the 27th seed, beat Florent Serra 7-6 (7/3) 6-1 6-4, 29th seed Igor Andreev saw off Russian countryman Evgeny Korolev 4-6 7-6 (7/2) 6-4 7-6 (7/4) and 28th seed Mardy Fish was leading Sergio Roitman 6-3 6-2 4-1 when the Argentinian retired.
Former semi-finalist Xavier Malisse was forced to qualify for the tournament after dropping to 170th in the world but his run was ended today by 18th seed Rainer Schuettler, who triumphed 6-7 (9/11) 6-4 7-6 (7/3) 6-1. Albert Montanes, the 32nd seed, eased past Grega Zemlja 6-4 6-4 6-4.
The tightest match of the day was out on Court 13 where Spain's Nicolas Almagro beat Juan Monaco of Argentina 6-7 (3/7) 6-7 (7/9) 7-6 (7/5) 6-4 8-6.